7MXG

PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06855800

7MXG の概要

• エントリーDOI: 10.2210/pdb7mxg/pdb
• 分子名称: Protein arginine N-methyltransferase 5, Methylosome protein 50, 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total)
• 機能のキーワード: arginine, methyl, transferase, transferase-transcription complex, transferase/transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 225302.87

構造登録者

McTigue, M.,Deng, Y.L.,Liu, W.,Brooun, A. (登録日: 2021-05-19, 公開日: 2021-11-17, 最終更新日: 2023-10-18)

• 主引用文献: Jensen-Pergakes, K.,Tatlock, J.,Maegley, K.A.,McAlpine, I.J.,McTigue, M.,Xie, T.,Dillon, C.P.,Wang, Y.,Yamazaki, S.,Spiegel, N.,Shi, M.,Nemeth, A.,Miller, N.,Hendrickson, E.,Lam, H.,Sherrill, J.,Chung, C.Y.,McMillan, E.A.,Bryant, S.K.,Palde, P.,Braganza, J.,Brooun, A.,Deng, Y.L.,Goshtasbi, V.,Kephart, S.E.,Kumpf, R.A.,Liu, W.,Patman, R.L.,Rui, E.,Scales, S.,Tran-Dube, M.,Wang, F.,Wythes, M.,Paul, T.A.; SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.; Mol.Cancer Ther., 21:3-15, 2022; PubMed: 34737197; DOI: 10.1158/1535-7163.MCT-21-0620

実験手法

X-RAY DIFFRACTION (2.395 Å)