7MU5

Human DCTPP1 bound to Triptolide

7MU5 の概要

• エントリーDOI: 10.2210/pdb7mu5/pdb
• 分子名称: dCTP pyrophosphatase 1, MAGNESIUM ION, triptolide, ... (4 entities in total)
• 機能のキーワード: inhibitor, pyrophosphatase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 104520.08

構造登録者

Hauk, G.,Berger, J.M. (登録日: 2021-05-14, 公開日: 2022-08-24, 最終更新日: 2023-10-18)

• 主引用文献: Liu, J.,He, Q.-L.,Zhou, J.,Chikarmane, R.V.,Hauk, G.,Rachakonda, A.,Vaghasia, A.M.,Castagna, N.,Steinberg, R.C.,Anders, N.M.,Wanjiku, T.M.,Nuhn, P.,Shim, J.S.,Giovinazzo, H.,Esopi, D.M.,Kim, K.,Coulter, J.,Wang, R.,Zhou, J.,Rudek, M.A.,Berger, J.M.,Liu, J.O.,Nelson, W.G.,Yegnasubramanian, S.; Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance; To Be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)