7MSB

Structure of EED bound to EEDi-4259

7MSB の概要

• エントリーDOI: 10.2210/pdb7msb/pdb
• 分子名称: Polycomb protein EED, (9aM,12aS)-12-{[(5-fluoro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,11,12a-tetraazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one (3 entities in total)
• 機能のキーワード: polycomb repressive complex 2, gene regulation-inhibitor complex, gene regulation/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42893.58

構造登録者

Petrunak, E.,Stuckey, J. (登録日: 2021-05-11, 公開日: 2021-10-20, 最終更新日: 2024-04-03)

• 主引用文献: Rej, R.K.,Wang, C.,Lu, J.,Wang, M.,Petrunak, E.,Zawacki, K.P.,McEachern, D.,Yang, C.Y.,Wang, L.,Li, R.,Chinnaswamy, K.,Wen, B.,Sun, D.,Stuckey, J.A.,Zhou, Y.,Chen, J.,Tang, G.,Wang, S.; Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.; J.Med.Chem., 64:14540-14556, 2021; PubMed: 34613724; DOI: 10.1021/acs.jmedchem.1c01059

実験手法

X-RAY DIFFRACTION (1.9 Å)