7MRB
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to NC-III-53
Summary for 7MRB
| Entry DOI | 10.2210/pdb7mrb/pdb |
| Descriptor | Bromodomain-containing protein 4, N-[4-(4-chlorophenoxy)-3-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)phenyl]ethanesulfonamide (3 entities in total) |
| Functional Keywords | bromosporine, brd4, brd, bet, gene regulation |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 15568.33 |
| Authors | Chan, A.,Schonbrunn, E. (deposition date: 2021-05-07, release date: 2022-08-03, Last modification date: 2023-10-18) |
| Primary citation | Guan, X.,Cheryala, N.,Karim, R.M.,Chan, A.,Berndt, N.,Qi, J.,Georg, G.I.,Schonbrunn, E. Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J.Med.Chem., 65:10441-10458, 2022 Cited by PubMed: 35867655DOI: 10.1021/acs.jmedchem.2c00453 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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