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7MR5

Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-052

Summary for 7MR5
Entry DOI10.2210/pdb7mr5/pdb
DescriptorBromodomain-containing protein 4, N,N'-{oxybis[(ethane-2,1-diyl)oxy(1-oxoethane-2,1-diyl)piperidine-1,4-diyl]}bis{4-[(4-{4-chloro-3-[(2-methylpropane-2-sulfonyl)amino]anilino}-5-methylpyrimidin-2-yl)amino]-2-fluorobenzamide}, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbromosporine, brd4, brd, bet, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight31689.28
Authors
Chan, A.,Schonbrunn, E. (deposition date: 2021-05-07, release date: 2022-05-18, Last modification date: 2023-10-18)
Primary citationGuan, X.,Cheryala, N.,Karim, R.M.,Chan, A.,Berndt, N.,Qi, J.,Georg, G.I.,Schonbrunn, E.
Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity.
J.Med.Chem., 65:10441-10458, 2022
Cited by
PubMed: 35867655
DOI: 10.1021/acs.jmedchem.2c00453
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.82 Å)
Structure validation

221051

건을2024-06-12부터공개중

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