7MQU

The haddock model of GDP KRas in complex with promethazine using NMR chemical shift perturbations

Summary for 7MQU

• Entry DOI: 10.2210/pdb7mqu/pdb
• NMR Information: BMRB: 30906
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: kras, allosteric inhibitor, drug discovery, haddock, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20023.69

Authors

Wang, X.,Gorfe, A.A.,Putkey, J.P. (deposition date: 2021-05-06, release date: 2022-05-11, Last modification date: 2024-05-15)

• Primary citation: Wang, X.,Gorfe, A.A.,Putkey, J.A.; Antipsychotic phenothiazine drugs bind to KRAS in vitro.; J.Biomol.Nmr, 75:233-244, 2021; PubMed: 34176062; DOI: 10.1007/s10858-021-00371-z

Experimental method

SOLUTION NMR