7MQP

E. coli dihydrofolate reductase complexed with 4'-chloro-3'-(4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl)-[1,1'-biphenyl]-4-carboxamide (UCP1228)

7MQP の概要

• エントリーDOI: 10.2210/pdb7mqp/pdb
• 分子名称: Dihydrofolate reductase, 3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-4'-methyl[1,1'-biphenyl]-4-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, antifolate, dhfr, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19334.53

構造登録者

Lombardo, M.N.,Wright, D.L. (登録日: 2021-05-06, 公開日: 2022-05-11, 最終更新日: 2023-10-18)

• 主引用文献: Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L.; Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.; Commun Biol, 5:459-459, 2022; PubMed: 35562546; DOI: 10.1038/s42003-022-03384-y

実験手法

X-RAY DIFFRACTION (2.1 Å)