7MOZ
Structure of HDAC2 in complex with a macrocyclic inhibitor (compound 25)
Summary for 7MOZ
Entry DOI | 10.2210/pdb7moz/pdb |
Descriptor | Histone deacetylase 2, ZINC ION, SULFATE ION, ... (7 entities in total) |
Functional Keywords | histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 133224.70 |
Authors | |
Primary citation | Yu, W.,Fells, J.,Clausen, D.,Liu, J.,Klein, D.J.,Christine Chung, C.,Myers, R.W.,Wu, J.,Wu, G.,Howell, B.J.,Barnard, R.J.O.,Kozlowski, J. Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorg.Med.Chem.Lett., 47:128168-128168, 2021 Cited by PubMed: 34091041DOI: 10.1016/j.bmcl.2021.128168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.543 Å) |
Structure validation
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