7MOG
Crystal Structure of Arabidopsis thaliana Plant and Fungi Atypical Dual Specificity Phosphatase 1(AtPFA-DSP1 ) Cys150Ser in complex with 5-PCF2 Am-InsP5, an analogue of 5-InsP7
7MOG の概要
エントリーDOI | 10.2210/pdb7mog/pdb |
分子名称 | Tyrosine-protein phosphatase DSP1, (1,1-difluoro-2-oxo-2-{[(1s,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]amino}ethyl)phosphonic acid (3 entities in total) |
機能のキーワード | inositol, inositol pyrophosphate, transferase, hydrolase, cell-signaling, phosphatase, substrate recognition, reaction mechanism, intermediate, phosphate, metaphosphate, molecular dynamic simulation, self-activation, catalytic water |
由来する生物種 | Arabidopsis thaliana (Mouse-ear cress) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 40759.68 |
構造登録者 | |
主引用文献 | Wang, H.,Perera, L.,Jork, N.,Zong, G.,Riley, A.M.,Potter, B.V.L.,Jessen, H.J.,Shears, S.B. A structural expose of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop. Nat Commun, 13:2231-2231, 2022 Cited by PubMed: 35468885DOI: 10.1038/s41467-022-29673-y 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
構造検証レポート
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