7MO7

Cryo-EM structure of 2:2 c-MET/HGF holo-complex

7MO7 の概要

• エントリーDOI: 10.2210/pdb7mo7/pdb
• EMDBエントリー: 23919
• 分子名称: Hepatocyte growth factor, Hepatocyte growth factor receptor, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose (3 entities in total)
• 機能のキーワード: c-met, hgf, receptor tyrosine kinase, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 479691.33

構造登録者

Uchikawa, E.,Chen, Z.M.,Xiao, G.Y.,Zhang, X.W.,Bai, X.C. (登録日: 2021-05-01, 公開日: 2021-06-09, 最終更新日: 2021-07-28)

• 主引用文献: Uchikawa, E.,Chen, Z.,Xiao, G.Y.,Zhang, X.,Bai, X.C.; Structural basis of the activation of c-MET receptor.; Nat Commun, 12:4074-4074, 2021; PubMed: 34210960; DOI: 10.1038/s41467-021-24367-3

実験手法

ELECTRON MICROSCOPY (4.8 Å)