7MMO

LY-CoV1404 neutralizing antibody against SARS-CoV-2

7MMO の概要

• エントリーDOI: 10.2210/pdb7mmo/pdb
• 分子名称: LY-CoV1404 Fab heavy chain, LY-CoV1404 Fab light chain, Spike protein S1, ... (5 entities in total)
• 機能のキーワード: antibody neutralizing sars-cov-2, immune system, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 140789.90

構造登録者

Hendle, J.,Pustilnik, A.,Sauder, J.M.,Coleman, K.A.,Boyles, J.S.,Dickinson, C.D. (登録日: 2021-04-30, 公開日: 2021-05-12, 最終更新日: 2023-10-18)

• 主引用文献: Westendorf, K.,Wang, L.,Zentelis, S.,Foster, D.,Vaillancourt, P.,Wiggin, M.,Lovett, E.,van der Lee, R.,Hendle, J.,Pustilnik, A.,Sauder, J.M.,Kraft, L.,Hwang, Y.,Siegel, R.W.,Chen, J.,Heinz, B.A.,Higgs, R.E.,Kallewaard, N.,Jepson, K.,Goya, R.,Smith, M.A.,Collins, D.W.,Pellacani, D.,Xiang, P.,de Puyraimond, V.,Ricicova, M.,Devorkin, L.,Pritchard, C.,O'Neill, A.,Dalal, K.,Panwar, P.,Dhupar, H.,Garces, F.A.,Cohen, C.,Dye, J.,Huie, K.E.,Badger, C.V.,Kobasa, D.,Audet, J.,Freitas, J.J.,Hassanali, S.,Hughes, I.,Munoz, L.,Palma, H.C.,Ramamurthy, B.,Cross, R.W.,Geisbert, T.W.,Menacherry, V.,Lokugamage, K.,Borisevich, V.,Lanz, I.,Anderson, L.,Sipahimalani, P.,Corbett, K.S.,Yang, E.S.,Zhang, Y.,Shi, W.,Zhou, T.,Choe, M.,Misasi, J.,Kwong, P.D.,Sullivan, N.J.,Graham, B.S.,Fernandez, T.L.,Hansen, C.L.,Falconer, E.,Mascola, J.R.,Jones, B.E.,Barnhart, B.C.; LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.; Biorxiv, 2022; PubMed: 33972947; DOI: 10.1101/2021.04.30.442182

実験手法

X-RAY DIFFRACTION (2.427 Å)