7MM0

Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain

7MM0 の概要

• エントリーDOI: 10.2210/pdb7mm0/pdb
• EMDBエントリー: 23498 23915
• 分子名称: B1-182.1 Fab heavy chain, B1-182.1 Fab light chain, Spike glycoprotein, ... (6 entities in total)
• 機能のキーワード: sars-cov-2, receptor-binding domain, antibody, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 456901.10

構造登録者

Zhou, T.,Tsybovsky, T.,Kwong, P.D. (登録日: 2021-04-29, 公開日: 2021-07-28, 最終更新日: 2021-08-25)

• 主引用文献: Wang, L.,Zhou, T.,Zhang, Y.,Yang, E.S.,Schramm, C.A.,Shi, W.,Pegu, A.,Oloniniyi, O.K.,Henry, A.R.,Darko, S.,Narpala, S.R.,Hatcher, C.,Martinez, D.R.,Tsybovsky, Y.,Phung, E.,Abiona, O.M.,Antia, A.,Cale, E.M.,Chang, L.A.,Choe, M.,Corbett, K.S.,Davis, R.L.,DiPiazza, A.T.,Gordon, I.J.,Hait, S.H.,Hermanus, T.,Kgagudi, P.,Laboune, F.,Leung, K.,Liu, T.,Mason, R.D.,Nazzari, A.F.,Novik, L.,O'Connell, S.,O'Dell, S.,Olia, A.S.,Schmidt, S.D.,Stephens, T.,Stringham, C.D.,Talana, C.A.,Teng, I.T.,Wagner, D.A.,Widge, A.T.,Zhang, B.,Roederer, M.,Ledgerwood, J.E.,Ruckwardt, T.J.,Gaudinski, M.R.,Moore, P.L.,Doria-Rose, N.A.,Baric, R.S.,Graham, B.S.,McDermott, A.B.,Douek, D.C.,Kwong, P.D.,Mascola, J.R.,Sullivan, N.J.,Misasi, J.; Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.; Science, 373:-, 2021; PubMed: 34210892; DOI: 10.1126/science.abh1766

実験手法

ELECTRON MICROSCOPY (3.15 Å)