7MK5

Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene

7MK5 の概要

• エントリーDOI: 10.2210/pdb7mk5/pdb
• 分子名称: ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 620629.89

構造登録者

Culp, E.J.,Sychantha, D.,Hobson, C.,Pawlowski, A.J.,Prehna, G.,Wright, G.D. (登録日: 2021-04-21, 公開日: 2022-02-02, 最終更新日: 2024-04-03)

• 主引用文献: Culp, E.J.,Sychantha, D.,Hobson, C.,Pawlowski, A.C.,Prehna, G.,Wright, G.D.; ClpP inhibitors are produced by a widespread family of bacterial gene clusters.; Nat Microbiol, 7:451-462, 2022; PubMed: 35246663; DOI: 10.1038/s41564-022-01073-4

実験手法

X-RAY DIFFRACTION (2.95 Å)