7MI6
Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Model 1
Summary for 7MI6
Entry DOI | 10.2210/pdb7mi6/pdb |
EMDB information | 23841 |
Descriptor | Fusion protein of Dynein and Endolysin, (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | aaa atpase, atpase inhibitor, motor protein |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Total number of polymer chains | 1 |
Total formula weight | 306384.82 |
Authors | Santarossa, C.C.,Urnavicius, L.,Coudray, N.,Ekeirt, D.C.,Bhabha, G.,Kapoor, T.M. (deposition date: 2021-04-16, release date: 2021-05-26, Last modification date: 2024-05-29) |
Primary citation | Santarossa, C.C.,Mickolajczyk, K.J.,Steinman, J.B.,Urnavicius, L.,Chen, N.,Hirata, Y.,Fukase, Y.,Coudray, N.,Ekiert, D.C.,Bhabha, G.,Kapoor, T.M. Targeting allostery in the Dynein motor domain with small molecule inhibitors. Cell Chem Biol, 28:1460-1473.e15, 2021 Cited by PubMed: 34015309DOI: 10.1016/j.chembiol.2021.04.024 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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