7MI6

Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Model 1

7MI6 の概要

• エントリーDOI: 10.2210/pdb7mi6/pdb
• EMDBエントリー: 23841
• 分子名称: Fusion protein of Dynein and Endolysin, (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: aaa atpase, atpase inhibitor, motor protein
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 306384.82

構造登録者

Santarossa, C.C.,Urnavicius, L.,Coudray, N.,Ekeirt, D.C.,Bhabha, G.,Kapoor, T.M. (登録日: 2021-04-16, 公開日: 2021-05-26, 最終更新日: 2024-05-29)

• 主引用文献: Santarossa, C.C.,Mickolajczyk, K.J.,Steinman, J.B.,Urnavicius, L.,Chen, N.,Hirata, Y.,Fukase, Y.,Coudray, N.,Ekiert, D.C.,Bhabha, G.,Kapoor, T.M.; Targeting allostery in the Dynein motor domain with small molecule inhibitors.; Cell Chem Biol, 28:1460-1473.e15, 2021; PubMed: 34015309; DOI: 10.1016/j.chembiol.2021.04.024

実験手法

ELECTRON MICROSCOPY (3.9 Å)