7MGQ
AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans
Summary for 7MGQ
Entry DOI | 10.2210/pdb7mgq/pdb |
Descriptor | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, MAGNESIUM ION (3 entities in total) |
Functional Keywords | isomerase, ligand, complex, structural protein |
Biological source | Cryptococcus neoformans |
Total number of polymer chains | 4 |
Total formula weight | 262032.13 |
Authors | Wizrah, M.S.,Chua, S.M.H.,Luo, Z.,Manik, M.K.,Pan, M.,Whyte, J.M.,Robertson, A.B.,Kappler, U.,Kobe, B.,Fraser, J.A. (deposition date: 2021-04-13, release date: 2022-04-20, Last modification date: 2023-10-18) |
Primary citation | Wizrah, M.S.I.,Chua, S.M.H.,Luo, Z.,Manik, M.K.,Pan, M.,Whyte, J.M.L.,Robertson, A.A.B.,Kappler, U.,Kobe, B.,Fraser, J.A. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J.Biol.Chem., 298:102453-102453, 2022 Cited by PubMed: 36063996DOI: 10.1016/j.jbc.2022.102453 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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