7MGL

Structure of human TRPML1 with ML-SI3

Summary for 7MGL

Entry DOI	10.2210/pdb7mgl/pdb
EMDB information	23828
Descriptor	Mucolipin-1, N-{(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide, 1,2-Distearoyl-sn-glycerophosphoethanolamine (3 entities in total)
Functional Keywords	trpml, calcium, ml-si3, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	265050.55
Authors	Schmiege, P.,Li, X. (deposition date: 2021-04-12, release date: 2021-06-16, Last modification date: 2021-11-17)
Primary citation	Schmiege, P.,Fine, M.,Li, X. Atomic insights into ML-SI3 mediated human TRPML1 inhibition. Structure, 29:1295-1302.e3, 2021 Cited by PubMed: 34171299 DOI: 10.1016/j.str.2021.06.003 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation