7MGJ

TNNI3K complexed with N-methyl-4-(4-(3-(3-(trifluoromethyl) phenyl) ureido) phenoxy)picolinamide

7MGJ の概要

• エントリーDOI: 10.2210/pdb7mgj/pdb
• 分子名称: Serine/threonine-protein kinase TNNI3K, N-methyl-4-[4-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]pyridine-2-carboxamide (3 entities in total)
• 機能のキーワード: kinase, cark, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 150376.93

構造登録者

Shewchuk, L.M. (登録日: 2021-04-12, 公開日: 2021-11-10, 最終更新日: 2024-04-03)

• 主引用文献: Patterson, J.R.,Graves, A.P.,Stoy, P.,Cheung, M.,Desai, T.A.,Fries, H.,Gatto Jr., G.J.,Holt, D.A.,Shewchuk, L.,Totoritis, R.,Wang, L.,Kallander, L.S.; Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38 alpha , and B-Raf.; J.Med.Chem., 64:15651-15670, 2021; PubMed: 34699203; DOI: 10.1021/acs.jmedchem.1c00700

実験手法