7MFC
Crystal structure of CSF1R in complex with vimseltinib
Summary for 7MFC
Entry DOI | 10.2210/pdb7mfc/pdb |
Descriptor | Macrophage colony-stimulating factor 1 receptor, Vimseltinib (3 entities in total) |
Functional Keywords | cancer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39071.67 |
Authors | Abendroth, J.,Davies, D.R.,Atkins, K. (deposition date: 2021-04-08, release date: 2021-11-24, Last modification date: 2023-10-18) |
Primary citation | Smith, B.D.,Kaufman, M.D.,Wise, S.C.,Ahn, Y.M.,Caldwell, T.M.,Leary, C.B.,Lu, W.P.,Tan, G.,Vogeti, L.,Vogeti, S.,Wilky, B.A.,Davis, L.E.,Sharma, M.,Ruiz-Soto, R.,Flynn, D.L. Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages. Mol.Cancer Ther., 20:2098-2109, 2021 Cited by PubMed: 34433663DOI: 10.1158/1535-7163.MCT-21-0361 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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