7MD8

Crystal structure of Staphylococcus aureus cystathionine gamma lyase holoenzyme Y103N mutant co-crystallized with NL2

7MD8 の概要

• エントリーDOI: 10.2210/pdb7md8/pdb
• 分子名称: Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, PYRIDOXAL-5'-PHOSPHATE, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: amino-acid biosynthesis, cysteine biosynthesis, hydrogen sulfide production, plp dependent enzyme, lyase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42452.54

構造登録者

Nuthanakanti, A.,Serganov, A.,Kaushik, A. (登録日: 2021-04-03, 公開日: 2021-06-23, 最終更新日: 2023-11-15)

• 主引用文献: Shatalin, K.,Nuthanakanti, A.,Kaushik, A.,Shishov, D.,Peselis, A.,Shamovsky, I.,Pani, B.,Lechpammer, M.,Vasilyev, N.,Shatalina, E.,Rebatchouk, D.,Mironov, A.,Fedichev, P.,Serganov, A.,Nudler, E.; Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance.; Science, 372:1169-1175, 2021; PubMed: 34112687; DOI: 10.1126/science.abd8377

実験手法

X-RAY DIFFRACTION (2.06 Å)