7MD4
Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists
Summary for 7MD4
Entry DOI | 10.2210/pdb7md4/pdb |
EMDB information | 23766 |
Descriptor | Isoform Short of Insulin receptor subunit alpha, Isoform Short of Insulin receptor, Insulin chain A, ... (4 entities in total) |
Functional Keywords | insulin receptor, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 242476.99 |
Authors | Gomez-Llorente, Y.,Zhou, H.,Scapin, G. (deposition date: 2021-04-03, release date: 2022-02-23, Last modification date: 2022-03-02) |
Primary citation | Wu, M.,Carballo-Jane, E.,Zhou, H.,Zafian, P.,Dai, G.,Liu, M.,Lao, J.,Kelly, T.,Shao, D.,Gorski, J.,Pissarnitski, D.,Kekec, A.,Chen, Y.,Previs, S.F.,Scapin, G.,Llorente, Y.G.,Hollingsworth, S.A.,Yan, L.,Feng, D.,Huo, P.,Walford, G.,Erion, M.D.,Kelley, D.E.,Lin, S.,Mu, J. Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13:942-942, 2022 Cited by PubMed: 35177603DOI: 10.1038/s41467-022-28561-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.5 Å) |
Structure validation
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