7MCE
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol
7MCE の概要
エントリーDOI | 10.2210/pdb7mce/pdb |
分子名称 | Bromodomain-containing protein 4, 2-{(7P)-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-3-yl}propan-2-ol (3 entities in total) |
機能のキーワード | bromodomain-containing protein 4 isoform long, brd4, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein sgc, cell cycle |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15721.10 |
構造登録者 | |
主引用文献 | Hill, M.D.,Quesnelle, C.,Tokarski, J.,Fang, H.,Fanslau, C.,Haarhoff, Z.,Kramer, M.,Madari, S.,Wiebesiek, A.,Morrison, J.,Simmermacher-Mayer, J.,Sinz, M.,Westhouse, R.,Xie, C.,Zhao, J.,Huang, L.,Sheriff, S.,Yan, C.,Marsilio, F.,Everlof, G.,Zvyaga, T.,Lee, F.,Gavai, A.V.,Degnan, A.P. Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype. Bioorg.Med.Chem.Lett., 51:128376-128376, 2021 Cited by PubMed: 34560263DOI: 10.1016/j.bmcl.2021.128376 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.76 Å) |
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