7MB3

SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM145

7MB3 の概要

• エントリーDOI: 10.2210/pdb7mb3/pdb
• 分子名称: 3C-like proteinase, N-{3-[(prop-2-yn-1-yl)oxy]propanoyl}-D-phenylalanyl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total)
• 機能のキーワード: sars-cov-2, covid-19, covid19 protease, protease inhibitor, covalent inhibitor, complex, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 206749.76

構造登録者

Lockbaum, G.J.,Schiffer, C.A. (登録日: 2021-03-31, 公開日: 2022-10-12, 最終更新日: 2023-10-18)

• 主引用文献: Lockbaum, G.J.,Schiffer, C.A.; SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor SM145; To Be Published,

実験手法

X-RAY DIFFRACTION (1.81 Å)