7M6U
Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase G2
Summary for 7M6U
Entry DOI | 10.2210/pdb7m6u/pdb |
Related | 1CG2 6XJ5 |
Descriptor | Carboxypeptidase G2 circular permuation pro-domain fusion, ZINC ION, SULFATE ION, ... (4 entities in total) |
Functional Keywords | pro-enzyme, enzyme design, directed enzyme-prodrug therapy, methotrexate, circular permutation, hydrolase |
Biological source | Pseudomonas sp. (strain RS-16) More |
Total number of polymer chains | 4 |
Total formula weight | 190273.35 |
Authors | Yachnin, B.J.,Khare, S.D. (deposition date: 2021-03-26, release date: 2021-04-14, Last modification date: 2023-10-18) |
Primary citation | Yachnin, B.J.,Azouz, L.R.,White 3rd, R.E.,Minetti, C.A.S.A.,Remeta, D.P.,Tan, V.M.,Drake, J.M.,Khare, S.D. Massively parallel, computationally guided design of a proenzyme. Proc.Natl.Acad.Sci.USA, 119:e2116097119-e2116097119, 2022 Cited by PubMed: 35377786DOI: 10.1073/pnas.2116097119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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