7M67

NMR Structure of Schistocin-1 antimicrobial peptide in presence of DPC-d38 micelles

7M67 の概要

• エントリーDOI: 10.2210/pdb7m67/pdb
• NMR情報: BMRB: 30891
• 分子名称: Schistocin-1 antimicrobial peptide (1 entity in total)
• 機能のキーワード: antimicrobial peptide, antimicrobial protein
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2276.78

構造登録者

Santos, B.P.O.,De Magalhaes, M.T.Q. (登録日: 2021-03-25, 公開日: 2021-09-15, 最終更新日: 2024-11-20)

主引用文献

Santos, B.P.O.,Alves, E.S.F.,Ferreira, C.S.,Ferreira-Silva, A.,Goes-Neto, A.,Verly, R.M.,Liao, L.M.,Oliveira, S.C.,de Magalhaes, M.T.Q.
Schistocins: Novel antimicrobial peptides encrypted in the Schistosoma mansoni Kunitz Inhibitor SmKI-1.
Biochim Biophys Acta Gen Subj, 1865:129989-129989, 2021

PubMed Abstract: Here we describe a new class of cryptides (peptides encrypted within a larger protein) with antimicrobial properties, named schistocins, derived from SmKI-1, a key protein in Shistosoma mansoni survival. This is a multi-functional protein with biotechnological potential usage as a therapeutic molecule in inflammatory diseases and to control schistosomiasis.

PubMed: 34389467
DOI: 10.1016/j.bbagen.2021.129989

実験手法

SOLUTION NMR