7M62
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2
Summary for 7M62
Entry DOI | 10.2210/pdb7m62/pdb |
EMDB information | 23686 23687 23688 23689 |
Descriptor | Islet amyloid polypeptide (1 entity in total) |
Functional Keywords | hiapp, type ii diabetes, amyloid, protein fibril |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 10 |
Total formula weight | 39073.12 |
Authors | Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2021-03-25, release date: 2021-09-22) |
Primary citation | Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Abskharon, R.,Saelices, L.,Nguyen, B.A.,Lu, J.,Murray, K.A.,Kandeel, F.,Eisenberg, D.S. Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28:724-730, 2021 Cited by DOI: 10.1038/s41594-021-00646-xPDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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