7M24

Human carbonic anhydrase II in complex with (R)-rosiglitazone

7M24 の概要

• エントリーDOI: 10.2210/pdb7m24/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, (R)-ROSIGLITAZONE, ... (4 entities in total)
• 機能のキーワード: glitazone drug class, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29493.62

構造登録者

Mueller, S.L.,Peat, T.S. (登録日: 2021-03-16, 公開日: 2022-02-02, 最終更新日: 2023-10-18)

• 主引用文献: Mueller, S.L.,Chrysanthopoulos, P.K.,Halili, M.A.,Hepburn, C.,Nebl, T.,Supuran, C.T.,Nocentini, A.,Peat, T.S.,Poulsen, S.A.; The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors-A Spin-Off Discovery from Fragment Screening.; Molecules, 26:-, 2021; PubMed: 34070212; DOI: 10.3390/molecules26103010

実験手法

X-RAY DIFFRACTION (1.3 Å)