7M20
18-mer HeLa-tubulin rings in complex with Cryptophycin 1
Summary for 7M20
Entry DOI | 10.2210/pdb7m20/pdb |
Related | 7LXB 7M18 |
EMDB information | 23569 23615 23627 |
Descriptor | Tubulin beta-3 chain, Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | anti-tumor, microtubule, tubulin-rings, polymerization-inhibitor, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 18 |
Total formula weight | 920767.72 |
Authors | Eren, E. (deposition date: 2021-03-15, release date: 2021-09-08, Last modification date: 2024-05-29) |
Primary citation | Eren, E.,Watts, N.R.,Sackett, D.L.,Wingfield, P.T. Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297:101138-101138, 2021 Cited by PubMed: 34461087DOI: 10.1016/j.jbc.2021.101138 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.84 Å) |
Structure validation
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