7M16

Triazole-based BET family bromodomain inhibitor bound to BRD4(D1)

Summary for 7M16

• Entry DOI: 10.2210/pdb7m16/pdb
• Descriptor: Bromodomain-containing protein 4, 4-{5-[6-(3,5-dimethylanilino)pyridin-2-yl]-4-methyl-1H-1,2,3-triazol-1-yl}piperidine-1-carboximidamide (3 entities in total)
• Functional Keywords: inhibitor, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15503.89

Authors

Johnson, J.A.,Pomerantz, W. (deposition date: 2021-03-12, release date: 2021-09-29, Last modification date: 2023-10-18)

• Primary citation: Carlson, A.S.,Cui, H.,Divakaran, A.,Johnson, J.A.,Brunner, R.M.,Pomerantz, W.C.K.,Topczewski, J.J.; Systematically Mitigating the p38alpha Activity of Triazole-based BET Inhibitors; ACS Med. Chem. Lett., 10:1296-1301, 2019; DOI: 10.1021/acsmedchemlett.9b00227

Experimental method

X-RAY DIFFRACTION (1.42 Å)