7M0N

The crystal structure of wild type PA endonuclease (A/Vietnam/1203/2004) in complex with Raltegravir

Summary for 7M0N

• Entry DOI: 10.2210/pdb7m0n/pdb
• Descriptor: Protein PA-X, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: nuclease, influenza, inhibitor resistance, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Influenza A virus (A/ruddy turnstone/New Jersey/Sg-00524/2008(H4N6)); More
• Total number of polymer chains: 4
• Total formula weight: 91109.98

Authors

Cuypers, M.G.,Slavish, P.J.,Yun, M.K.,Dubois, R.,Rankovic, Z.,White, S.W. (deposition date: 2021-03-11, release date: 2022-03-02, Last modification date: 2023-10-25)

• Primary citation: Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W.; Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.; Eur.J.Med.Chem., 247:115035-115035, 2023; PubMed: 36603507; DOI: 10.1016/j.ejmech.2022.115035

Experimental method

X-RAY DIFFRACTION (2.4 Å)