7M0N
The crystal structure of wild type PA endonuclease (A/Vietnam/1203/2004) in complex with Raltegravir
7M0N の概要
エントリーDOI | 10.2210/pdb7m0n/pdb |
分子名称 | Protein PA-X, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, MANGANESE (II) ION, ... (6 entities in total) |
機能のキーワード | nuclease, influenza, inhibitor resistance, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
由来する生物種 | Influenza A virus (A/ruddy turnstone/New Jersey/Sg-00524/2008(H4N6)) 詳細 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 91109.98 |
構造登録者 | Cuypers, M.G.,Slavish, P.J.,Yun, M.K.,Dubois, R.,Rankovic, Z.,White, S.W. (登録日: 2021-03-11, 公開日: 2022-03-02, 最終更新日: 2023-10-25) |
主引用文献 | Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W. Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247:115035-115035, 2023 Cited by PubMed: 36603507DOI: 10.1016/j.ejmech.2022.115035 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
構造検証レポート
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