7M0K
HPK1 IN COMPLEX WITH COMPOUND 1
Summary for 7M0K
Entry DOI | 10.2210/pdb7m0k/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, 4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide (3 entities in total) |
Functional Keywords | hpk1 hematopoietic progenitor kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 131508.96 |
Authors | Lesburg, C.A. (deposition date: 2021-03-11, release date: 2021-04-07, Last modification date: 2024-04-03) |
Primary citation | Vara, B.A.,Levi, S.M.,Achab, A.,Candito, D.A.,Fradera, X.,Lesburg, C.A.,Kawamura, S.,Lacey, B.M.,Lim, J.,Methot, J.L.,Xu, Z.,Xu, H.,Smith, D.M.,Piesvaux, J.A.,Miller, J.R.,Bittinger, M.,Ranganath, S.H.,Bennett, D.J.,DiMauro, E.F.,Pasternak, A. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. Acs Med.Chem.Lett., 12:653-661, 2021 Cited by PubMed: 33859804DOI: 10.1021/acsmedchemlett.1c00096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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