7LYB

Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c

Summary for 7LYB

• Entry DOI: 10.2210/pdb7lyb/pdb
• EMDB information: 23590 23591 23592
• Descriptor: Histone H3.1, ZINC ION, Histone H4, ... (10 entities in total)
• Functional Keywords: nucleosome core particle, chromatin, brca1, bard1, ubch5c, dna repair, dna double-strand break, homologous recombination, 53bp1, structural protein-dna complex, structural protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 13
• Total formula weight: 241828.64

Authors

Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, D.,Mer, E.,Mer, G. (deposition date: 2021-03-06, release date: 2021-07-28, Last modification date: 2021-09-01)

• Primary citation: Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, E.,Mer, G.; Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.; Nature, 596:438-443, 2021; PubMed: 34321665; DOI: 10.1038/s41586-021-03716-8

Experimental method

ELECTRON MICROSCOPY (3.28 Å)