7LXV
Structure of human 20S proteasome with bound MPI-5
Summary for 7LXV
Entry DOI | 10.2210/pdb7lxv/pdb |
EMDB information | 23576 |
Descriptor | Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-5, ... (15 entities in total) |
Functional Keywords | proteasome, plasmodium falciparum, malaria, drug, bortezomib, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 28 |
Total formula weight | 718455.80 |
Authors | Metcalfe, R.D.,Morton, C.J.,Liu, B.,Xie, S.C.,Hanssen, E.,Leis, A.P.,Tilley, L.,Griffin, M.D.W. (deposition date: 2021-03-05, release date: 2021-09-22, Last modification date: 2022-04-13) |
Primary citation | Xie, S.C.,Metcalfe, R.D.,Mizutani, H.,Puhalovich, T.,Hanssen, E.,Morton, C.J.,Du, Y.,Dogovski, C.,Huang, S.C.,Ciavarri, J.,Hales, P.,Griffin, R.J.,Cohen, L.H.,Chuang, B.C.,Wittlin, S.,Deni, I.,Yeo, T.,Ward, K.E.,Barry, D.C.,Liu, B.,Gillett, D.L.,Crespo-Fernandez, B.F.,Ottilie, S.,Mittal, N.,Churchyard, A.,Ferguson, D.,Aguiar, A.C.C.,Guido, R.V.C.,Baum, J.,Hanson, K.K.,Winzeler, E.A.,Gamo, F.J.,Fidock, D.A.,Baud, D.,Parker, M.W.,Brand, S.,Dick, L.R.,Griffin, M.D.W.,Gould, A.E.,Tilley, L. Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34548400DOI: 10.1073/pnas.2107213118 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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