7LXV

Structure of human 20S proteasome with bound MPI-5

7LXV の概要

• エントリーDOI: 10.2210/pdb7lxv/pdb
• EMDBエントリー: 23576
• 分子名称: Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-5, ... (15 entities in total)
• 機能のキーワード: proteasome, plasmodium falciparum, malaria, drug, bortezomib, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 718455.80

構造登録者

Metcalfe, R.D.,Morton, C.J.,Liu, B.,Xie, S.C.,Hanssen, E.,Leis, A.P.,Tilley, L.,Griffin, M.D.W. (登録日: 2021-03-05, 公開日: 2021-09-22, 最終更新日: 2022-04-13)

• 主引用文献: Xie, S.C.,Metcalfe, R.D.,Mizutani, H.,Puhalovich, T.,Hanssen, E.,Morton, C.J.,Du, Y.,Dogovski, C.,Huang, S.C.,Ciavarri, J.,Hales, P.,Griffin, R.J.,Cohen, L.H.,Chuang, B.C.,Wittlin, S.,Deni, I.,Yeo, T.,Ward, K.E.,Barry, D.C.,Liu, B.,Gillett, D.L.,Crespo-Fernandez, B.F.,Ottilie, S.,Mittal, N.,Churchyard, A.,Ferguson, D.,Aguiar, A.C.C.,Guido, R.V.C.,Baum, J.,Hanson, K.K.,Winzeler, E.A.,Gamo, F.J.,Fidock, D.A.,Baud, D.,Parker, M.W.,Brand, S.,Dick, L.R.,Griffin, M.D.W.,Gould, A.E.,Tilley, L.; Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34548400; DOI: 10.1073/pnas.2107213118

実験手法

ELECTRON MICROSCOPY (3.4 Å)