7LXN

Cryo-EM structure of EDC-crosslinked ConM SOSIP.v7 (ConM-EDC) in complex with bNAb PGT122

Summary for 7LXN

• Entry DOI: 10.2210/pdb7lxn/pdb
• EMDB information: 23572
• Descriptor: HIV-1 Env glycoprotein gp120, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: env, sosip, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 394585.70

Authors

Martin, G.M.,Ward, A.B.,Sattentau, Q.J. (deposition date: 2021-03-04, release date: 2022-03-09, Last modification date: 2023-09-20)

• Primary citation: Martin, G.M.,Russell, R.A.,Mundsperger, P.,Harris, S.,Jovanoska, L.,Trajano, L.F.,Schiffner, T.,Fabian, K.,Tolazzi, M.,Scarlatti, G.,McFarlane, L.,Cheeseman, H.,Aldon, Y.,Schermer, E.E.,Breemen, M.,Sliepen, K.,Katinger, D.,Kunert, R.,Sanders, R.W.,Shattock, R.,Ward, A.B.,Sattentau, Q.J.; Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens.; Npj Vaccines, 8:101-101, 2023; PubMed: 37443366; DOI: 10.1038/s41541-023-00696-w

Experimental method

ELECTRON MICROSCOPY (3.85 Å)