7LU9

Cryo-EM structure of DH851.3 bound to HIV-1 CH505 Env

7LU9 の概要

• エントリーDOI: 10.2210/pdb7lu9/pdb
• 関連するPDBエントリー: 6XRJ 7L02 7L06 7L09 7L6M 7L6O
• EMDBエントリー: 23518 23519
• 分子名称: DH851.3 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• 機能のキーワード: fab-dimerized, glycan-reactive, antibodies, hiv-1, dh898.1, fab-dimer, glycan-reactive neutralizing antibody, macaque hiv-1 vaccine-induced, b cell lineage, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Macaca mulatta (Rhesus monkey); 詳細
• タンパク質・核酸の鎖数: 18
• 化学式量合計: 500612.40

構造登録者

Manne, K.,Edwards, R.J.,Acharya, P. (登録日: 2021-02-21, 公開日: 2021-03-24, 最終更新日: 2021-06-09)

• 主引用文献: Williams, W.B.,Meyerhoff, R.R.,Edwards, R.J.,Li, H.,Manne, K.,Nicely, N.I.,Henderson, R.,Zhou, Y.,Janowska, K.,Mansouri, K.,Gobeil, S.,Evangelous, T.,Hora, B.,Berry, M.,Abuahmad, A.Y.,Sprenz, J.,Deyton, M.,Stalls, V.,Kopp, M.,Hsu, A.L.,Borgnia, M.J.,Stewart-Jones, G.B.E.,Lee, M.S.,Bronkema, N.,Moody, M.A.,Wiehe, K.,Bradley, T.,Alam, S.M.,Parks, R.J.,Foulger, A.,Oguin, T.,Sempowski, G.D.,Bonsignori, M.,LaBranche, C.C.,Montefiori, D.C.,Seaman, M.,Santra, S.,Perfect, J.,Francica, J.R.,Lynn, G.M.,Aussedat, B.,Walkowicz, W.E.,Laga, R.,Kelsoe, G.,Saunders, K.O.,Fera, D.,Kwong, P.D.,Seder, R.A.,Bartesaghi, A.,Shaw, G.M.,Acharya, P.,Haynes, B.F.; Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.; Cell, 184:2955-, 2021; PubMed: 34019795; DOI: 10.1016/j.cell.2021.04.042

実験手法

ELECTRON MICROSCOPY (5.6 Å)