7LTX
EGFR (T790M/V948R) in complex with quinazolinone allosteric inhibitor
Summary for 7LTX
Entry DOI | 10.2210/pdb7ltx/pdb |
Descriptor | Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | egfr, kinase, allosteric, inhibitor, quinazolinone, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 155235.00 |
Authors | Beyett, T.S.,Eck, M.J. (deposition date: 2021-02-20, release date: 2022-02-23, Last modification date: 2023-10-18) |
Primary citation | Gero, T.W.,Heppner, D.E.,Beyett, T.S.,To, C.,Azevedo, S.C.,Jang, J.,Bunnell, T.,Feru, F.,Li, Z.,Shin, B.H.,Soroko, K.M.,Gokhale, P.C.,Gray, N.S.,Janne, P.A.,Eck, M.J.,Scott, D.A. Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg.Med.Chem.Lett., 68:128718-128718, 2022 Cited by PubMed: 35378251DOI: 10.1016/j.bmcl.2022.128718 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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