7LTL

STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH AN INHIBITOR LACKING A ZINC BINDING GROUP (COMPOUND 19)

7LTL の概要

• エントリーDOI: 10.2210/pdb7ltl/pdb
• 分子名称: Histone deacetylase 2, ZINC ION, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: histone deacetylase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 133124.11

構造登録者

Klein, D.J.,Beshore, D.C. (登録日: 2021-02-19, 公開日: 2021-05-05, 最終更新日: 2024-03-06)

• 主引用文献: Beshore, D.C.,Adam, G.C.,Barnard, R.J.O.,Burlein, C.,Gallicchio, S.N.,Holloway, M.K.,Krosky, D.,Lemaire, W.,Myers, R.W.,Patel, S.,Plotkin, M.A.,Powell, D.A.,Rada, V.,Cox, C.D.,Coleman, P.J.,Klein, D.J.,Wolkenberg, S.E.; Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.; Acs Med.Chem.Lett., 12:540-547, 2021; PubMed: 33854701; DOI: 10.1021/acsmedchemlett.1c00074

実験手法

X-RAY DIFFRACTION (1.49 Å)