7LT6

Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP

Summary for 7LT6

• Entry DOI: 10.2210/pdb7lt6/pdb
• Related: 7LSW
• Descriptor: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein (2 entities in total)
• Functional Keywords: autophagy, atg8, lir, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 49000.79

Authors

Appleton, B.A. (deposition date: 2021-02-18, release date: 2021-10-13, Last modification date: 2023-10-18)

• Primary citation: Goodwin, J.M.,Walkup 4th, W.G.,Hooper, K.,Li, T.,Kishi-Itakura, C.,Ng, A.,Lehmberg, T.,Jha, A.,Kommineni, S.,Fletcher, K.,Garcia-Fortanet, J.,Fan, Y.,Tang, Q.,Wei, M.,Agrawal, A.,Budhe, S.R.,Rouduri, S.R.,Baird, D.,Saunders, J.,Kiselar, J.,Chance, M.R.,Ballabio, A.,Appleton, B.A.,Brumell, J.H.,Florey, O.,Murphy, L.O.; GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.; Sci Adv, 7:eabj2485-eabj2485, 2021; PubMed: 34597140; DOI: 10.1126/sciadv.abj2485

Experimental method

X-RAY DIFFRACTION (1.8 Å)