7LS9

Cryo-EM structure of neutralizing antibody 1-57 in complex with prefusion SARS-CoV-2 spike glycoprotein

7LS9 の概要

• エントリーDOI: 10.2210/pdb7ls9/pdb
• EMDBエントリー: 23506
• 分子名称: Spike glycoprotein, 1-57 Fab heavy chain, 1-57 Fab light chain, ... (6 entities in total)
• 機能のキーワード: neutralizing antibody, fusion protein, spike glycoprotein, covid-19, rbd, rbd-directed antibody, 1-57, viral protein, immune system, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 592526.31

構造登録者

Cerutti, G.,Shapiro, L. (登録日: 2021-02-17, 公開日: 2021-03-17, 最終更新日: 2021-09-29)

• 主引用文献: Cerutti, G.,Rapp, M.,Guo, Y.,Bahna, F.,Bimela, J.,Reddem, E.R.,Yu, J.,Wang, P.,Liu, L.,Huang, Y.,Ho, D.D.,Kwong, P.D.,Sheng, Z.,Shapiro, L.; Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies.; Structure, 29:655-663.e4, 2021; PubMed: 34111408; DOI: 10.1016/j.str.2021.05.014

実験手法

ELECTRON MICROSCOPY (3.42 Å)