7LRS

Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody A23-58.1 that targets the receptor-binding domain

Summary for 7LRS

• Entry DOI: 10.2210/pdb7lrs/pdb
• Related: 7LRT
• EMDB information: 23498 23499 23915
• Descriptor: Spike glycoprotein, antibody A23-58.1 heavy chain, antibody A23-58.1 light chain, ... (5 entities in total)
• Functional Keywords: sars-cov-2, receptor-binding domain, antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 3
• Total formula weight: 71322.45

Authors

Zhou, T.,Tsybovsky, Y. (deposition date: 2021-02-17, release date: 2021-07-14, Last modification date: 2021-08-25)

• Primary citation: Wang, L.,Zhou, T.,Zhang, Y.,Yang, E.S.,Schramm, C.A.,Shi, W.,Pegu, A.,Oloniniyi, O.K.,Henry, A.R.,Darko, S.,Narpala, S.R.,Hatcher, C.,Martinez, D.R.,Tsybovsky, Y.,Phung, E.,Abiona, O.M.,Antia, A.,Cale, E.M.,Chang, L.A.,Choe, M.,Corbett, K.S.,Davis, R.L.,DiPiazza, A.T.,Gordon, I.J.,Hait, S.H.,Hermanus, T.,Kgagudi, P.,Laboune, F.,Leung, K.,Liu, T.,Mason, R.D.,Nazzari, A.F.,Novik, L.,O'Connell, S.,O'Dell, S.,Olia, A.S.,Schmidt, S.D.,Stephens, T.,Stringham, C.D.,Talana, C.A.,Teng, I.T.,Wagner, D.A.,Widge, A.T.,Zhang, B.,Roederer, M.,Ledgerwood, J.E.,Ruckwardt, T.J.,Gaudinski, M.R.,Moore, P.L.,Doria-Rose, N.A.,Baric, R.S.,Graham, B.S.,McDermott, A.B.,Douek, D.C.,Kwong, P.D.,Mascola, J.R.,Sullivan, N.J.,Misasi, J.; Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.; Science, 373:-, 2021; PubMed: 34210892; DOI: 10.1126/science.abh1766

Experimental method

ELECTRON MICROSCOPY (3.89 Å)