7LQ7

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV503 and COVA1-16

7LQ7 の概要

• エントリーDOI: 10.2210/pdb7lq7/pdb
• 分子名称: Spike protein S1, CV503 heavy chain, CV503 light chain, ... (6 entities in total)
• 機能のキーワード: antibody, coronavirus, fab, spike, covid-19, rbd, receptor binding domain, immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 354301.03

構造登録者

Yuan, M.,Zhu, X.,Wilson, I.A. (登録日: 2021-02-13, 公開日: 2021-09-15, 最終更新日: 2023-10-18)

• 主引用文献: Cho, H.,Gonzales-Wartz, K.K.,Huang, D.,Yuan, M.,Peterson, M.,Liang, J.,Beutler, N.,Torres, J.L.,Cong, Y.,Postnikova, E.,Bangaru, S.,Talana, C.A.,Shi, W.,Yang, E.S.,Zhang, Y.,Leung, K.,Wang, L.,Peng, L.,Skinner, J.,Li, S.,Wu, N.C.,Liu, H.,Dacon, C.,Moyer, T.,Cohen, M.,Zhao, M.,Lee, F.E.,Weinberg, R.S.,Douagi, I.,Gross, R.,Schmaljohn, C.,Pegu, A.,Mascola, J.R.,Holbrook, M.,Nemazee, D.,Rogers, T.F.,Ward, A.B.,Wilson, I.A.,Crompton, P.D.,Tan, J.; Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.; Sci Transl Med, 13:eabj5413-eabj5413, 2021; PubMed: 34519517; DOI: 10.1126/scitranslmed.abj5413

実験手法

X-RAY DIFFRACTION (3.4 Å)