7LPJ

APE1 Mn-bound phosphorothioate substrate complex with abasic ribonucleotide DNA

Summary for 7LPJ

• Entry DOI: 10.2210/pdb7lpj/pdb
• Descriptor: DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-R(P*(YA4))-D(P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... (5 entities in total)
• Functional Keywords: dna repair, abasic ribonucleotide, ap-endonuclease, lyase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 75165.17

Authors

Freudenthal, B.D.,Hoitsma, N.M. (deposition date: 2021-02-11, release date: 2021-08-04, Last modification date: 2023-10-18)

• Primary citation: Hoitsma, N.M.,Click, T.H.,Agarwal, P.K.,Freudenthal, B.D.; Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker.; Comput Struct Biotechnol J, 19:3293-3302, 2021; PubMed: 34188778; DOI: 10.1016/j.csbj.2021.05.035

Experimental method

X-RAY DIFFRACTION (2.56 Å)