7LPH

APE1 Mn-bound product complex with abasic ribonucleotide DNA

7LPH の概要

• エントリーDOI: 10.2210/pdb7lph/pdb
• 分子名称: DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (6 entities in total)
• 機能のキーワード: dna repair, abasic ribonucleotide, ap-endonuclease, lyase, lyase-dna complex, lyase/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 75104.14

構造登録者

Freudenthal, B.D.,Hoitsma, N.M. (登録日: 2021-02-11, 公開日: 2021-08-04, 最終更新日: 2023-10-18)

• 主引用文献: Hoitsma, N.M.,Click, T.H.,Agarwal, P.K.,Freudenthal, B.D.; Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker.; Comput Struct Biotechnol J, 19:3293-3302, 2021; PubMed: 34188778; DOI: 10.1016/j.csbj.2021.05.035

実験手法

X-RAY DIFFRACTION (1.99 Å)