7LOV
Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and noeuromycin
Summary for 7LOV
Entry DOI | 10.2210/pdb7lov/pdb |
Descriptor | Toxin B, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | inhibitors, tcdb, toxin, kinetic isotope effects, kies, drug design, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Clostridioides difficile (Peptoclostridium difficile) |
Total number of polymer chains | 2 |
Total formula weight | 130332.68 |
Authors | Harijan, R.K.,Paparella, A.S.,Aboulache, B.L.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2021-02-10, release date: 2021-11-17, Last modification date: 2023-10-18) |
Primary citation | Paparella, A.S.,Aboulache, B.L.,Harijan, R.K.,Potts, K.S.,Tyler, P.C.,Schramm, V.L. Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nat Commun, 12:6285-6285, 2021 Cited by PubMed: 34725358DOI: 10.1038/s41467-021-26580-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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