7LOV

Crystal structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP and noeuromycin

7LOV の概要

• エントリーDOI: 10.2210/pdb7lov/pdb
• 分子名称: Toxin B, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: inhibitors, tcdb, toxin, kinetic isotope effects, kies, drug design, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Clostridioides difficile (Peptoclostridium difficile)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 130332.68

構造登録者

Harijan, R.K.,Paparella, A.S.,Aboulache, B.L.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (登録日: 2021-02-10, 公開日: 2021-11-17, 最終更新日: 2023-10-18)

• 主引用文献: Paparella, A.S.,Aboulache, B.L.,Harijan, R.K.,Potts, K.S.,Tyler, P.C.,Schramm, V.L.; Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.; Nat Commun, 12:6285-6285, 2021; PubMed: 34725358; DOI: 10.1038/s41467-021-26580-6

実験手法

X-RAY DIFFRACTION (2.5 Å)