7LO6
Structure of CD4 mimetic BNM-III-170 in complex with BG505 SOSIP.664 HIV-1 Env trimer and 17b Fab
Summary for 7LO6
Entry DOI | 10.2210/pdb7lo6/pdb |
EMDB information | 23462 |
Descriptor | Envelope glycoprotein BG505 SOSIP.664 gp120, ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-5-(methylaminomethyl)-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41, ... (10 entities in total) |
Functional Keywords | cd4m, fusion, hiv-1, entry, viral protein, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 12 |
Total formula weight | 373980.74 |
Authors | |
Primary citation | Jette, C.A.,Barnes, C.O.,Kirk, S.M.,Melillo, B.,Smith III, A.B.,Bjorkman, P.J. Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nat Commun, 12:1950-1950, 2021 Cited by PubMed: 33782388DOI: 10.1038/s41467-021-21816-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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