7LNM

Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclopentene-1-carboxylic acid

Summary for 7LNM

Entry DOI	10.2210/pdb7lnm/pdb
Descriptor	Ornithine aminotransferase, mitochondrial, (1~{R},3~{S},4~{R})-3-methyl-4-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]cyclopentane-1-carboxylic acid (3 entities in total)
Functional Keywords	ornithine aminotransferase, oat, aminotransferase, inactivator, inhibitor, transferase, transferase-inactivator complex, transferase/inactivator
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	271395.78
Authors	Butrin, A.,Catlin, D.,Zhu, W.,Liu, D.,Silverman, R. (deposition date: 2021-02-07, release date: 2021-08-25, Last modification date: 2023-10-18)
Primary citation	Zhu, W.,Doubleday, P.F.,Butrin, A.,Weerawarna, P.M.,Melani, R.D.,Catlin, D.S.,Dwight, T.A.,Liu, D.,Kelleher, N.L.,Silverman, R.B. Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143:8193-8207, 2021 Cited by PubMed: 34014654 DOI: 10.1021/jacs.1c03572 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation