7LM4

The crystal structure of the I38T mutant PA Endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988503

Summary for 7LM4

Entry DOI	10.2210/pdb7lm4/pdb
Related	6VL3
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, ... (6 entities in total)
Functional Keywords	nuclease, influenza, inhibitor resistance, viral protein
Biological source	Influenza A virus (strain swl A/California/04/2009 H1N1)
Total number of polymer chains	1
Total formula weight	24598.63
Authors	Cuypers, M.G.,Slavish, P.J.,Jayaraman, S.,Rankovic, Z.,White, S.W. (deposition date: 2021-02-05, release date: 2022-02-09, Last modification date: 2023-10-18)
Primary citation	Slavish, P.J.,Cuypers, M.G.,Rimmer, M.A.,Abdolvahabi, A.,Jeevan, T.,Kumar, G.,Jarusiewicz, J.A.,Vaithiyalingam, S.,Jones, J.C.,Bowling, J.J.,Price, J.E.,DuBois, R.M.,Min, J.,Webby, R.J.,Rankovic, Z.,White, S.W. Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247:115035-115035, 2023 Cited by PubMed: 36603507 DOI: 10.1016/j.ejmech.2022.115035 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation